FTO and acute myeloid leukemia: Additionally, to determine the effects of FTO on the invasion of AML cells, transwell assays were conducted in THP-1 and MV411 cells after knockdown of FTO. The results showed that downregulation of FTO significantly attenuated THP-1 and MV411 cells migration and invasion (p < 0.001) (Fig. S7a and Fig. S7b).