Five known cell types were identified based on previously reported cell markers and other AML single-cell sequencing results [22], including 18,491 HSCs corresponding to cell markers CD34, SPINK2, and CYTL1, 20,274 Myeloids corresponding to cell markers LYZ, CST3, and MS4A7, 13,640 erythrocytes corresponding to cell markers HBB, HBA1, and GATA1, 1459 TCells corresponding to cell markers CD3D, CD3E, and TRAC, and 945 B cells corresponding to cell markers MS4A1, CD79A, and CD79B (Fig. 1b) (Fig. S1). The gene discussed is LYZ; the disease is acute myeloid leukemia.