Noteworthily, Prohep elevated Helicobacter typhlonius inversely correlated to tumor count < 2 mm (p < 0.05), and pro-inflammatory cytokines TNF-α (p < 0.05), while being positively correlated to the abundance of fecal butyrate, propionate and acetate (p < 0.05) (Fig. 5A). This evidence concerns the gene TNF and neoplasm.