This has stimulated the search of ENPP1 inhibitors with potential application in cancer immunotherapy (Carozza et al. 2020; Cogan and Bakhoum 2020; Onyedibe et al. 2019; Rauf et al. 2023; Ruiz-Fernández de Córdoba et al. 2023). The gene discussed is ENPP1; the disease is cancer.