(iv) Finally, an important function attributed to ENPP1 is the inhibition of the insulin receptor tyrosine kinase, which has a role in the insulin resistance of non-insulin-dependent diabetes mellitus (Arianti et al. 2021; Goldfine et al. 1998; Goldfine et al. 2008; Goldfine et al. 1999; Maddux et al. 1995; Roberts et al. 2019; Teno et al. 1999). This evidence concerns the gene ENPP1 and diabetes mellitus.