To determine if this finding would reproduce in an independent cohort, we performed CHIP mutation calling using whole exome sequencing (WES) data of median ~80× depth from 180 additional peripheral blood mononuclear cell (PBMC) samples from an independent cohort of NSCLC patients (Figure 2C–E, Figure 2—figure supplement 3, Supplementary file 1a, c, d and Methods). The gene discussed is STUB1; the disease is non-small cell lung carcinoma.