We also constructed a malignant intestinal tumor model by introducing ApcΔ716, KrasG12D, Tgfbr2−/−, and Trp53R270H mutations to generate quadruple-mutant mouse model (12) and showed that missense-type mutant p53 promotes the survival and clonal expansion ability of single cell–dissociated cancer cells, which may contribute to colonization of disseminated cells in distant organs (13). This evidence concerns the gene TP53 and intestinal neoplasm.