As αvβ8 plays an important role in controlling inflammation associated with the development of fibrosis [79,80] through activation of TGFβ, it will be important to understand how to best target αvβ8 in the TME as systemic blocking of TGFβ activation may have unwanted effects on autoimmunity [27]. The gene discussed is TGFB1; the disease is Autoimmunity.