VEGFA and Alzheimer disease: Overall VEGF communication strength (calculated by summing communication probabilities of all curated VEGF pathway ligand–receptor (L–R) pairs among all cell types) (Table S5 in supporting information) was significantly reduced (Wilcoxon test; P < 0.05) in the AD group compared to the cognitively normal group, and the reduction was observed for both incoming and outgoing VEGF signaling strength (calculated by in‐degree and out‐degree network centrality scores, respectively) among cells (Figure 2A).