Several types of malignancies show aberrant expression of miR-151a-3p, which is linked to tumorigenesis.11,37 For instance, miR-151a-3p suppresses prostate cancer cell growth.11 In addition, SBF2-AS1 sponges miR-151a-3p to induce chemotherapy resistance in tumor cells.37 It is unknown, therefore, how miR-151a-3p affects the development of CCA. Here, SBF2 is linked to cholangiocarcinoma.