In addition, exploring lncRNA sponge miRNA-mediated drug resistance in rectal cancer offers innovative treatment avenues.28 For example, the LINC00461/miR-593-5p/CCND1 regulatory network may regulate cisplatin resistance in rectal cancer.29 Recent reports also mentioned the function of lncRNAs in colorectal cancer by modulating JAK/STAT signaling.30 Additionally, the prognostic significance of lncRNA DLGAP1-AS2 in regulating the Trim21/ELOA/LHPP network in colorectal cancer provided a new perspective for the treatment of the tumor.31 This evidence concerns the gene TRIM21 and colorectal cancer.