For instance, LncRNA GAS5 impedes the progression of CRC by engaging with and enhancing Yes-associated protein (YAP) phosphorylation.16 The LINC00460/DHX9/IGF2BP2 interaction complex augments CRC cell proliferation and metastasis by regulating the stability of HMGA1. This evidence concerns the gene IGF2BP2 and colorectal carcinoma.