TPI1, a key gene in C6_Hepatocyte-IL13RA2 and HCC metastasis, could participate in regulating the HCC immune microenvironment, and its expression was positively correlated with HCC metastasis and poor prognosis, while negatively correlated with CD8+ T cell infiltration.50 In another study, a glycolysis‐related prognostic model divided patients with HCC into high‐ and low‐risk groups, and in vitro analyses revealed that ZFP41 played a crucial role in cell viability, proliferation, migration, invasion, and glycolysis.51 This evidence concerns the gene IL13RA2 and hepatocellular carcinoma.