Chronic infection by hepatitis C virus (HCV) depletes CD8+ T cells and promotes immune evasion through spontaneous viral escape and dysregulation of major histocompatibility complex I (MHC I) dependent antigen presentation.13,14 In alcoholic steatohepatitis (ASH), alcohol promotes the inhibition of liver immune response by increasing the abundance of M2 TAMs, inhibiting CD8+ T cell activation, and facilitating gMDSC infiltration. The gene discussed is CD8A; the disease is alcoholic fatty liver disease.