Intensive intercellular crosstalk among regulatory T (Treg) cells, regulatory DCs, exhausted CD8+ T cells, and C1QC+ TAMs may foster immunosuppression in HCC.39 TAM was also suggested to suppress tumor T cell infiltration.40 Furthermore, tumor-associated neutrophil (TAN) populations were found to be enriched and were associated with poor prognosis.22 Here, CD8A is linked to neoplasm.