STAT3 and RELA/p65 formed a complex in HepG2 hepatoblastoma cells stimulated with IL-1 and IL-6 (Hagihara et al., 2005), and NF-κB RELA/p65 homodimers were shown to cooperate with STAT3 in Hep3B cells in response to IL-1 (Yoshida et al., 2004). This evidence concerns the gene IL6 and hepatoblastoma.