TNFRSF1A and breast cancer: However, Stat3 gene targets elevated in the Fyn neurodegeneration model included tnfrsf1a; its human homolog (TNFRSF1A) encodes a receptor for TNF-α (also known as TNF) and is associated with activation of the NF-κB pathway in breast cancer (Egusquiaguirre et al., 2018).