The use of a miR let-7b-5p mimic in HepG2_HCC cells down-regulated IGF1R expression, inhibited the AKT/mTOR pathway, improved Ras/Raf signal transduction, and led to anti-tumor signaling in HCC xenograft mouse models by targeting GPC3 [126]. This evidence concerns the gene GPC3 and hepatocellular carcinoma.