The effect size for new diagnoses were: IBD (aHR: 0·69 [95 % CI: 0·51-0·93]), RhA (aHR: 1·23 [95 % CI: 0·70-2·16]), psoriasis (aHR: 1·00 [95 % CI: 0·89-1·12]), SLE (aHR: 1·25 [95 % CI: 0·56-2·77]), coeliac disease (aHR: 0·85 [95 % CI: 0·65-1·11]) and MS (aHR: 1·70 [95 % CI: 0·72-4·00]). The gene discussed is DHX9; the disease is systemic lupus erythematosus.