A total of 55 CpG sites were found to significantly impact the risk of 5 site-specific allergic diseases, with 4 CpG sites exhibiting cross-allergic effects: cg17272563 (PRRT1), cg03689048 (BAT3), cg20069688 (STK19), and cg20513976 (LIME1) (Fig. 3). Here, PRRT1 is linked to allergic disease.