Indeed, EVs from brains and spinal cords of the SOD1G93A ALS mouse model, as well as from the spinal cords of human familial ALS patients with SOD1 mutations, contained abundant misfolded, non-native, disulfide-cross-linked aggregated SOD1 (Silverman et al., 2019). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.