CEACAM1 and Insulin resistance: Similarly, L-SACC1 mice with liver-specific inactivation of CEACAM1 (overexpressing a dominant-negative phosphorylation-defective S503A isoform that evades sinusoidal localization)[40] displayed visceral obesity, insulin resistance, steatohepatitis and spontaneous hepatic fibrosis[55] in addition to exaggerated hepatic fibrosis when fed a high-fat diet[80].