EDN1 and Hepatic fibrosis: In keeping with the predominant expression of CEACAM1 in LSECs relative to the general endothelial pool in the liver, LSECs of VECadCre+Cc1fl/fl single, but not VECadCre+Et1.Cc1fl/fl double mutants, manifested cell injury, characteristic of hepatic fibrosis[76].