These observations were bolstered by the reversal of diet-induced insulin resistance and hepatic steatosis by acute adenoviral-mediated delivery of wild-type CEACAM1 to the liver[61] or by forced liver-specific over-expression of rat transgene using human Apolipoprotein A1 promoter that is induced by high-fat feeding[60]. This evidence concerns the gene CEACAM1 and Insulin resistance.