As detailed below, this alternative paradigm has been bolstered by the phenotype of mice with liver-specific loss-of-function of Ceacam1, the gene encoding CEACAM1 (L-SACC1 and AlbCre+Cc1fl/fl mutants)[54,55], and by the reversal of systemic insulin resistance and hepatic steatohepatitis in global Ceacam1 null mice when CEACAM1 is exclusively reconstituted in hepatocytes[56]. Here, CEACAM1 is linked to Insulin resistance.