Previous clinicopathological studies have shown that the expression of EZH2 is associated with the progression of HCC and various metastatic characteristics of HCC, including venous invasion, direct liver invasion, and the absence of tumor encapsulation [8].Yang et al. demonstrated that immune-related RNA-binding proteins (RBPs) could predict the prognosis of patients with HCC and constructed a prognostic model. This evidence concerns the gene EZH2 and hepatocellular carcinoma.