CD276 promotes epithelial-mesenchymal transition (EMT) and HCC invasion through the JAK2/STAT3/slug pathway [39] and induces M2 polarization of tumor-associated macrophages (TAMs) to promote an immunosuppressive tumor microenvironment (TME) in a STAT3-dependent manner [40]. Here, JAK2 is linked to hepatocellular carcinoma.