PANK1 and chorea-acanthocytosis: However, neuroimaging and genetic testing are very important for the exact diagnosis of CHAC due to overlapping clinical features in CHAC and other syndromes, including McLeod syndrome (MLS), pantothenate kinase-associated neurodegeneration (PKAN), Huntington's disease-like 2 (HDL2), other forms of inherited chorea (such as Huntington's disease), other forms of Huntington's-like disorders, and other syndromes of neurodegeneration with brain iron accumulation (NBIAs).