Specifically, we examined the induction of IFNβ, ISGs such as interferon-induced transmembrane protein (IFITM), IFN regulatory factor 3 (IRF-3), IRF-7 and as well as antiviral genes, including myxovirus resistance 2 (MX2), MX1, 2′-5′ oligo adenylate synthetase 1 (OAS1g), OAS2 and OAS3 in context of SARS-CoV-2 and B.1.617.2 infections. The gene discussed is IRF7; the disease is infection.