As the effect of corylin was abrogated by treatment with EX527, (a sirtuin 1 (SIRT1) inhibitor) and L-748337 (a β3-adrenoceptor antagonist), the molecular mechanisms employed by corylin to enhance browning and lipolysis of adipocytes most likely involves SIRT1 and β3-adrenoceptor, suggesting that corylin may be therapeutically relevant for the treatment of obesity with both SIRTI and β3-adrenoceptor dependent pathways playing a vital role. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.