CYCS and gastric cancer: Apoptosis appears to be the main mechanism of HsCaNB-induced cell death in hepatoma and gastric cancer cells, causing mitochondrial depolarization in an HsCaNB-dependent manner, leading to the release of cytochrome c and the cleavage of the initiator caspase 9, a characteristic of numerous stimuli that cause apoptosis through the intrinsic pathway involving mitochondria [13, 46].