SOAT1 and rheumatoid arthritis: Finally, the PASS analysis confirmed the biological potential of C7 and C9 as promising targets for RA treatment, showing higher Pa values for inhibiting cyclooxygenase (responsible for pain and inflammation), MMPs (involved in cartilage destruction and bone erosion), JAK/STAT (crucial for aberrant signaling pathways), cytokines and chemokines (pivotal in RA pathogenesis), and specific inhibitors of the TCA cycle (facilitating the conversion of lactate in hypoxic environments, leading to increase inflammation) (Cai et al., 2020).