In silico analysis, utilizing CADD techniques such as network pharmacology, microarray validation, molecular docking, and MD simulations, identified the potential bioactive compound and targets that influence biological processes such as inflammation, apoptosis, and collagen degradation, as well as pathways like TNF signaling, HIF1 signaling, and osteoclast differentiation, which are crucial in managing RA. Here, TNF is linked to rheumatoid arthritis.