Additionally, the results of AH patients, NIAAA, and ALD mouse models have indicated that excessive alcohol consumption inhibits the ADRB2/SIRT1/PGC-1α/PPARα pathway, leading to elevated levels of oxidative stress and cytokines such as CCL2, CXCL8, and CXCL10, accompanied by hepatic steatosis (Figure 10). This evidence concerns the gene CXCL8 and steatosis.