IGHE and allergic disease: Furthermore, because most skin flora are not targeted by IgE, the specificity of the antibody for malassezial materials indicates a special affinity of the acarian PRR for Malassezia. For this reason, and because the increase in malassezial colonization that follows puberty coincides with the decrease in the incidence of allergy, it is reasonable to assume Malassezia is involved in the anti-acarian defense of humans.