To this day, numerous IGF-1 deficiency conditions have been described in humans,e.g. fetal growth restriction (FGR).8 FGR is a disorder where reduced levels in both IGF-1 and IGF-1 binding protein 3 (IGFBP-3) are observed, suggesting that reduced IGF-1 concentration in the fetus, mother and/or placenta may contribute to growth restriction.8,9 Also, FGR, among other harmful consequences, such as fetal death, miscarriage, low birth weight, premature birth and fetal alcohol spectrum disorders (FASD), can be a result of ethanol consumption during pregnancy .10,11. This evidence concerns the gene IGF1 and fetal growth restriction.