Our study aims to provide preliminary RV for plasma protein biomarkers including Aβ42/40 ratio, p-tau181, p-tau217, Nfl, GFAP, IL-1B, IL-10, and TNFα in a sample of adults in the Democratic Republic of Congo with and without dementia to aid in screening, future diagnostic utility, prognostication, and management of AD in the DRC. The gene discussed is NEFL; the disease is Alzheimer disease.