Furthermore, the expression of synaptophysin (SYP), postsynaptic density protein 95 (PSD-95), and microtubule-associated protein 2 (MAP-2) was considerably upregulated in the hippocampal regions of AD mice treated with NSCs, and spatial learning and memory were enhanced (Zhu et al., 2020). The gene discussed is DLG4; the disease is Alzheimer disease.