An AD amyloid precursor protein (APP)/progerin 1 (PS1) transgenic (Tg) mouse model was generated by seeding human brain-derived neural stem cells (hNSCs) by Xueyuan Li et al. In AD mice, hNSC transplantation corrected impairments in identification, learning, and memory but not in anxiety tests. This evidence concerns the gene PSEN1 and Alzheimer disease.