BV may also lead to a decrease in the secretion of secreted leukocyte protease inhibitor in the vagina, thereby weakening the body’s ability to inhibit the virus (30); simultaneously, it may reduce the secretion of IL-1β and other cytokines in the cervical epithelium, thus disrupting the immune balance of the body and making the body easily infected with HR-HPV (55, 56). This evidence concerns the gene IL1B and bacterial vaginosis.