APC and nervous system disorder: However, unexpectedly, we found that the mutations in the KIF2A motor domain, which diminish its depolymerase activity, and have been linked to a variety of neurodevelopmental and neurological disorders (Poirier et al., 2013; Ruiz-Reig et al., 2024), led to the formation of MT bundles and further the recruitment of endogenous APC to these bundles, suggesting that the altered APC localization may also contribute to KIF2A-related pathogenesis (Fig. S4D).