IL18 and infection: To achieve this, we co-transduced primary T cells with CAR19 LVs (multiplicity of infection [MOI] = 3) (allowing constitutive expression of a 4-1BB αCD19 CAR endowed with the A3B1 scFv clone)37 (Figure 1A, top) and LOP18 (MOI = 5) (for Dox-inducible expression of IL-18 using the LOP LV) (Figure 1A, bottom), resulting in a heterogeneous population of cells including CAR+IL-18+, CAR+IL-18−, CAR−IL-18+, and CAR−IL-18− cells (Figure S1A).