CRH and Anxiety: For example, intracerebroventricular OX administration in male Wistar rats led to an increase in anxiety-like behavior and dose-dependently reinstated operant cocaine seeking without altering intake, and it dramatically elevated intracranial self-stimulation thresholds, which was mediated by CRF (Boutrel et al., 2005; Hata et al., 2011; Suzuki et al., 2005).