This RESCUE AT-LVO sub-study demonstrated that the perioperative administration of P2Y12 inhibitors during EVT for anterior circulation TO, particularly in patients with occlusion at the c-ICA with ipsilateral intracranial artery occlusion, was associated with good functional outcomes without increasing the risk of hemorrhagic complications, and the same results were observed in those who also underwent CAS or received perioperative aspirin. This evidence concerns the gene P2RY12 and arterial occlusion.