Secondly, experimental studies have shown that magnesium deficiency is associated with acute inflammatory responses mediated by calcium, N-methyl-D-aspartate, and tumor necrosis factor-alpha (41), along with increases in C-reactive protein, interleukin-6, and fibrinogen (42–44), all of which are sensitive biomarkers of inflammation. The gene discussed is IL6; the disease is magnesium deficiency.