Notably, Interleukin-17 receptor D (IL-17RD), Interleukin-22 receptor subunit alpha-1 (IL22RA-1), Interleukin-20 receptor subunit alpha (IL20RA), Interleukin-22 (IL-22), Interleukin-23 receptor (IL-23R), and Single Ig IL-1-related receptor (SIGIRR) showed notable associations with ARDS. The gene discussed is IL22; the disease is acute respiratory distress syndrome.