Thus, GBM with EGFR variant III (EGFRvIII) amplification can exhibit higher proliferation rates due to increased de novo lipogenesis and overall metabolic activity [34]; increased expression of fatty acid synthase (FASN) in GBM cells promotes FA synthesis, thereby enhancing GBM cell migration and recurrence [35]; the upregulated expression of ATP‐citrate lyase (ACL) in GBM significantly promotes fatty acid and cholesterol synthesis to supply nutrients for GBM cell proliferation [36]. Here, ACLY is linked to glioblastoma.