SPP1 and neoplasm: This enables Spp1 to affect multiple cell types and their functions.[10, 27] Such broad activity suggests potential therapeutic modulation.[13, 33] Notably, mouse studies have provided revealing data, demonstrating that Spp1 knock‐out mice have lower TAM infiltration and tumor growth compared to wild‐type counterparts.[34, 35] Various therapeutic strategies for Spp1 inhibition have been explored, including the use of siRNA, shRNA, aptamers, antibodies, and small‐molecule inhibitors[13, 33] but efficacy has generally been modest.