TUBB3 and head and neck squamous cell carcinoma: Consistently, our results showed that treatment of HPV-negative HNSCC cell lines with SX-682 increased miR-200c and decreased the expression of tubulin beta-3 in vivo, thus potentially implicating the modulation of tubulin beta-3 in the mechanism of SX-682-mediated sensitization to docetaxel chemotherapy.