TSHR and Hashimoto thyroiditis: The patients described in the studies by Ohkubo et al. (2012) and Lo-Castro et al. (2011) exhibited classic signs of autoimmune hypothyroidism, such as elevated thyroid-stimulating hormone (TSH) and the presence of thyroid antibodies (anti-TSH receptor, antithyroid peroxidase, and antithyroglobulin)​​.