CCN2 and acute kidney injury: However, there were no differences in PDGF-β (data not shown), TGFβ1 and CTGF levels between the WT and PT-atg5 KO groups during the development of AKI (Supplementary Figure S4A–D), indicating that the absence of Atg5 in renal tubules did not affect the production of renal PDGF-β, TGFβ1, and CTGF after I/R.