GRM2 and acute disseminated encephalomyelitis: In conjunction with the ADE rat model, which mimics key characteristics of AUD-related pathophysiology and behavioral deficits, this approach provides a powerful translational toolbox showcased by investigating the effects of administering psilocybin and LY379268 which ultimately support recent suggestions of a 5-HT2AR-mGluR2-based approach to therapeutically target AUD.