Notably, studies using Rag2-/-, which results in an impaired adaptive immune system in mice34 have produced conflicting results with increased amyloid plaque pathology in Rag2−/−; 5xFAD mice35, and reduced pathology and decreased brain Aβ levels in Rag2−/−; PSAPP mice36. The gene discussed is RAG2; the disease is amyloidosis.