Since its discovery in 1993 [1], Bax is, therefore, one of the most widely studied regulators of programmed cell death (>45,000 publications are returned on the search string “(Bax) AND (apoptosis)” on pubmed at the time of writing), with numerous studies investigating (changes in) expression amounts and localization of Bax in various scenarios of cellular stress conditions and in models for proliferative and degenerative diseases, using antibody-based assays. Here, BAX is linked to neurodegenerative disease.