During their expansion from this region to other regions, such as clusters 6 and 3 regions, the tumor cells exhibited a more malignant expression pattern, such as high expression levels of malignant markers, such as TNC and TGFBI (Supplementary Fig. S5a and b), as well as active proliferation markers, such as FOS and WEE1 (Supplementary Fig. S5c). Here, TNC is linked to neoplasm.