In line with this spatial architecture, Katey et al. found neutrophils distinguished a unique microenvironment associated with tumor progression.58 Collectively, these findings suggest that CXCR1+ neutrophils not only increase in number but also penetrate deeper into tumor core areas after resistance to third-generation EGFR-TKIs, thus promoting the establishment of an immunosuppressive tumor immune microenvironment. The gene discussed is CXCR1; the disease is neoplasm.