MYC and cancer: Direct c-Myc small molecule stabilizers: KI-MS2-008 (5) is an asymmetric polycyclic lactam identified through screening of unbiased small molecule microarrays which represents a groundbreaking approach to combating Myc-driven cancers.249 KI-MS2-008 (5) directly binds to Max and stabilizes homodimer formation (IC50 = 2.15 μM after 3 days) which lead to mimicry of the effect of Myc loss.