Additionally, as a nucleating protein of SGs, G3BP1 binds mRNAs, 40S ribosomal subunits, initiation factors (eIF2, eIF3, eIF4), and RNA-binding proteins (e.g., poly(A) binding protein, Caprin1) for SGs assembly and protein translation arrest after viral infection. The gene discussed is EIF3A; the disease is viral infectious disease.