While the upregulation of NF-κB-dependent proinflammatory genes IL-6 and IL-1B were significantly suppressed by RAD51 in KDM1A deleted cells, therefore, we conclude that KDM1A epigenetically regulates RAD51 expression to suppress the NF-κB-dependent proinflammatory genes IL-6 and IL-1B, thus spatially blocking STING-associated anti-tumor immunity in sTILs in ESCC. The gene discussed is STING1; the disease is esophageal squamous cell carcinoma.