Further CFA data showed that deletion of KDM1A in RAD51 deficient ESCC cells did not significantly increase growth suppression in TE1 (Fig. 5Q, p < 0.0001) and K410 cells (Fig. 5R, p = 0.0278 for siRAD51 #3, p = 0.0032 for siRAD51 #3+siKDM1A #81), supporting that RAD51 is a direct downstream factor epigenetically regulated by KDM1A. Here, KDM1A is linked to esophageal squamous cell carcinoma.