It directly stimulates the proliferation, survival, and invasion of tumor cells, and induces production of pro-angiogenic cytokines that promote tumorigenesis in both immune and non-immune cells in the tumor microenvironment.481 Here, this review focuses on summarizing how IL-6 activates JAK/STAT signaling in neutrophils involved in the tumor immune response. The gene discussed is SOAT1; the disease is neoplasm.