The main fecal biomarkers of IBD activity are neutrophil granule proteins, such as calreticulin.608 Moreover, the detection of anti-granulocyte macrophage colony-stimulating factor autoantibodies (aGMAbs; also known as anti-GM-CSF antibodies) was demonstrated to contribute to predicting complicated ileal Crohn’s disease prior to diagnosis. The gene discussed is CSF2; the disease is inflammatory bowel disease.