ITGB2 and leukocyte adhesion deficiency: Disease severity in LAD-1 is also determined by CD18 expression.556 Patients with LAD inherited in an autosomal recessive (AR) manner frequently present with poor wound healing, delayed umbilical cord separation, neutrophilia, oral ulcers, and aggressive gingivitis with accelerated apical bone loss.557 HSCT has been successfully performed in several cases of LAD, with clinical symptom improvement.558