VSTM1 and gout: This process involves a variety of Src family tyrosine kinases, such as Lyn, Syk, and Tec.530 MSU crystals can also directly stimulate neutrophils to induce inflammation by downregulating the expression of two inhibitory receptors on the cell surface, including the myeloid inhibitory C-type lectin-like receptor (MICL) and the signal inhibitory receptor on leukocytes-1 (SIRL-1).531 One intriguing feature of acute gouty arthritis is its spontaneous resolution, typically within 7-10 days.532 Aggregated NETs are assumed to be a possible mechanism for the spontaneous resolution of gout.