INS and diabetic kidney disease: T2DM is characterized by insulin resistance due to the loss of insulin sensitivity in glucose-using peripheral tissues and insufficient insulin secretion by β-cells due to risk factors, such as obesity, an unhealthy diet, and exercise deficiency.537 The impact of neutrophils on diabetes is currently being studied more in the context of diabetic complications, including diabetic nephropathy, diabetic eye disease, and diabetic foot ulcers (DFUs).