NETs may also protect tumor cells from cytotoxic T cells, potentially compromising anti-PD-1 blockade therapy.225 Inhibition of NETosis with PAD4 and DNase I inhibitors has shown promise in enhancing CD8+ T cell infiltration, reducing tumor growth, and improving the cellular response to anti-PD-1 blockade therapy in colorectal cancer.226. The gene discussed is PADI4; the disease is neoplasm.