CXCR4 and neoplasm: They reduce neutrophil lifespan by upregulating the IFN-β-dependent death receptor Fas and regulating anti-apoptotic and pro-apoptotic protein expression to achieve a pro-apoptotic ratio.469 Moreover, Type I IFNs interfere with neutrophil recruitment by inhibiting the expression of CXCR2 and CXCR4 in tumor cells, preventing ligand binding.328 Type I IFNs also suppress tumor proliferation by inhibiting pro-angiogenic chemokines such as VEGF, MMP9, and CXCR2-related CXCL.328