SYK and neoplasm: In contrast, Syk kinases are activated through the interaction of their tandem Src homology 2 domains with ITAM domains,374 primarily regulating the activation of neutrophils by ICs through FcRγ,375 essential against various pathogens including bacteria and fungi.376,377 Both Src and Syk kinases have also been implicated in various cancers and are considered promising targets for tumor-specific therapies.378 However, their role in regulating the tumor immune response in neutrophils remains largely unexplored, presenting a promising avenue for future research.