A study focusing on the tau interactome in induced pluripotent stem cell (iPSC)-derived neurons, expressing either wild-type tau (control) or mutant tau associated with FTD (early-stage primary tauopathy model), showed significantly altered mutation-dependent interactions between tau and components of synaptic vesicles and mitochondria, affecting neuronal function and bioenergetics [62]. This evidence concerns the gene MAPT and frontotemporal dementia.