In addition, 0N3R wild-type tau-RING and 0N4R wild-type tau-RING baits could degrade their respective tau isoform aggregates in HEK293-T cells expressing either 0N3R or 0N4R tau that were seeded with AD (preferentially 3R tau) [158] or PSP (4R tauopathy) brain-derived tau, respectively. This evidence concerns the gene MAPT and Alzheimer disease.